||Molecular Structure Research Center
Founded in: 1994
Specialization: Research of molecular structure by Physical Chemistry methods: X-Ray Structural Analysis, NMR-, IR-, UV-, Mass- Spectroscopy, Chromatography.
Structure determination of organic compounds by various physicochemical methods. Structural investigations of pyrrolidine derivatives possessing antiviral properties. The study of interaction of biologically important gas molecules with sublimed layers of metalloporphyrins and creation of the stable layers with the selective co-ordination ability. 3D structure determination of biological and organic molecules by NMR spectroscopy in liquid crystals and weakly oriented environments.
The unique method for investigation of processes proceeding in gem-containing proteins has been developed. New metal-containing porphyrine complexes with oxygen, and carbon/nitrogen oxides have been obtained. For the first time the complex of NO2 with the gem-modeling porphyries has been produced. Coordinated oligomers with the microporous structures containing unsaturated metal-ions have been created. They exhibit many useful properties, particularly, selective sorption and allowing the solid-phase filling and storage of gases, for instance, of nitric oxide. On the base of this research, the sensitive sensors of the various gases can be developed.
Together with chemists the target-oriented search of anti- HIV-1 compounds has been done by revealing the structure-biological activity relationship using X-ray crystallography and theoretical calculations. In particular, by this approach a few compounds of classes 2-aryl- and 2-heteryl- prolynes with antiviral properties had been found. A set of new nonlinear optical monocrystals with unique properties had been produced on the basis of the studied interactions of aminoacids and their derivatives with the various inorganic and organic acids. The dependence of the magnetic properties on structures of new inorganic and semiorganic compounds with giant magnetic resistance has been investigated. These compounds are very attractive for the developers of the memory devices of new generation.
The method of the spatial structure determination of organic molecules and biomolecules in liquid phase on base of NMR spectroscopy in aligning media has been successfully extended. Specific solute-solvent interactions leading to artifacts and decreasing accuracy and precision of determined structure has been revealed. Methods for taking into account these effects and criteria for right choice of orienting media have been developed.
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